Enhancing the therapeutic activity of hyperimmune IgG against chikungunya virus using FcγRIIIa affinity chromatography

Enhancing the therapeutic activity of hyperimmune IgG against chikungunya virus using FcγRIIIa affinity chromatography

IntroductionChikungunya virus (CHIKV) is a re-emerging mosquito transmitted alphavirus of global concern. Neutralizing antibodies and antibody Fc-effector functions have been shown to reduce CHIKV disease and infection in animals. However, the ability to improve the therapeutic activity of CHIKV-spe...

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Bibliographic Details
Main Authors: Julie M. Fox, Vicky Roy, Bronwyn M. Gunn, Glen R. Bolton, Daved H. Fremont, Galit Alter, Michael S. Diamond, Austin W. Boesch
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
glycoform
antibody effector function
afucosylated
FcγRIIIa
chromatography
hyperimmune IgG
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1153108/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1153108/full

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