Roles of the ubiquitin proteasome system in the effects of drugs of abuse
Because of its ability to regulate the abundance of selected proteins the ubiquitin proteasome system (UPS) plays an important role in neuronal and synaptic plasticity. As a result various stages of learning and memory depend on UPS activity. Drug addiction, another phenomenon that relies on neuropl...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-01-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00099/full |
| _version_ | 1818340751509028864 |
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| author | Nicolas eMassaly Nicolas eMassaly Nicolas eMassaly Bernard eFrancés Bernard eFrancés Lionel eMoulédous Lionel eMoulédous |
| author_facet | Nicolas eMassaly Nicolas eMassaly Nicolas eMassaly Bernard eFrancés Bernard eFrancés Lionel eMoulédous Lionel eMoulédous |
| author_sort | Nicolas eMassaly |
| collection | DOAJ |
| description | Because of its ability to regulate the abundance of selected proteins the ubiquitin proteasome system (UPS) plays an important role in neuronal and synaptic plasticity. As a result various stages of learning and memory depend on UPS activity. Drug addiction, another phenomenon that relies on neuroplasticity, shares molecular substrates with memory processes. However the necessity of proteasome-dependent protein degradation for the development of addiction has been poorly studied. Here we first review evidences from the literature that drugs of abuse regulate the expression and activity of the UPS system in the brain. We then provide a list of proteins which have been shown to be targeted to the proteasome following drug treatment and could thus be involved in neuronal adaptations underlying behaviors associated with drug use and abuse. Finally we describe the few studies that addressed the need for UPS-dependent protein degradation in animal models of addiction-related behaviors. |
| first_indexed | 2024-12-13T15:47:53Z |
| format | Article |
| id | doaj.art-9d1d8a43a6234aa5a956aafbafe98581 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-13T15:47:53Z |
| publishDate | 2015-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-9d1d8a43a6234aa5a956aafbafe985812022-12-21T23:39:38ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992015-01-01710.3389/fnmol.2014.00099124443Roles of the ubiquitin proteasome system in the effects of drugs of abuseNicolas eMassaly0Nicolas eMassaly1Nicolas eMassaly2Bernard eFrancés3Bernard eFrancés4Lionel eMoulédous5Lionel eMoulédous6Centre de Recherches sur la Cognition Animale, CNRS UMR 5169IPBS CNRS UMR5089Université Paul Sabatier Toulouse IIICentre de Recherches sur la Cognition Animale, CNRS UMR 5169Université Paul Sabatier Toulouse IIIIPBS CNRS UMR5089Université Paul Sabatier Toulouse IIIBecause of its ability to regulate the abundance of selected proteins the ubiquitin proteasome system (UPS) plays an important role in neuronal and synaptic plasticity. As a result various stages of learning and memory depend on UPS activity. Drug addiction, another phenomenon that relies on neuroplasticity, shares molecular substrates with memory processes. However the necessity of proteasome-dependent protein degradation for the development of addiction has been poorly studied. Here we first review evidences from the literature that drugs of abuse regulate the expression and activity of the UPS system in the brain. We then provide a list of proteins which have been shown to be targeted to the proteasome following drug treatment and could thus be involved in neuronal adaptations underlying behaviors associated with drug use and abuse. Finally we describe the few studies that addressed the need for UPS-dependent protein degradation in animal models of addiction-related behaviors.http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00099/fullNicotineAddictionplasticityopioidstimulantsDrug abuse |
| spellingShingle | Nicolas eMassaly Nicolas eMassaly Nicolas eMassaly Bernard eFrancés Bernard eFrancés Lionel eMoulédous Lionel eMoulédous Roles of the ubiquitin proteasome system in the effects of drugs of abuse Frontiers in Molecular Neuroscience Nicotine Addiction plasticity opioid stimulants Drug abuse |
| title | Roles of the ubiquitin proteasome system in the effects of drugs of abuse |
| title_full | Roles of the ubiquitin proteasome system in the effects of drugs of abuse |
| title_fullStr | Roles of the ubiquitin proteasome system in the effects of drugs of abuse |
| title_full_unstemmed | Roles of the ubiquitin proteasome system in the effects of drugs of abuse |
| title_short | Roles of the ubiquitin proteasome system in the effects of drugs of abuse |
| title_sort | roles of the ubiquitin proteasome system in the effects of drugs of abuse |
| topic | Nicotine Addiction plasticity opioid stimulants Drug abuse |
| url | http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00099/full |
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