Dysregulated lysosomal exocytosis drives protease-mediated cartilage pathogenesis in multiple lysosomal disorders

Dysregulated lysosomal exocytosis drives protease-mediated cartilage pathogenesis in multiple lysosomal disorders

Summary: The classic view of the lysosome as a static recycling center has been replaced with one of a dynamic and mobile hub of metabolic regulation. This revised view raises new questions about how dysfunction of this organelle causes pathology in inherited lysosomal disorders. Here we provide evi...

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Bibliographic Details
Main Authors: Jen-Jie Lee, Tong Wang, Kali Wiggins, Po Nien Lu, Christina Underwood, Katarzyna Ochenkowska, Eric Samarut, Laura M. Pollard, Heather Flanagan-Steet, Richard Steet
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:iScience
Subjects:
Cell biology
Developmental biology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224005145

Internet

http://www.sciencedirect.com/science/article/pii/S2589004224005145

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