Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency.

Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency.

The pyruvate dehydrogenase (PDH) complex is localized in the mitochondrial matrix catalyzing the irreversible decarboxylation of pyruvate to acetyl-CoA and NADH. For proper complex regulation the E1-α subunit functions as an on/off switch regulated by phosphorylation/dephosphorylation. In different...

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Bibliographic Details
Main Authors: Ana Sofia Rodrigues, Marcelo Correia, Andreia Gomes, Sandro L Pereira, Tânia Perestrelo, Maria Inês Sousa, João Ramalho-Santos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4493017?pdf=render

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http://europepmc.org/articles/PMC4493017?pdf=render

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