Single nucleus multi-omics identifies human cortical cell regulatory genome diversity

Single nucleus multi-omics identifies human cortical cell regulatory genome diversity

Summary: Single-cell technologies measure unique cellular signatures but are typically limited to a single modality. Computational approaches allow the fusion of diverse single-cell data types, but their efficacy is difficult to validate in the absence of authentic multi-omic measurements. To compre...

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Bibliographic Details
Main Authors: Chongyuan Luo, Hanqing Liu, Fangming Xie, Ethan J. Armand, Kimberly Siletti, Trygve E. Bakken, Rongxin Fang, Wayne I. Doyle, Tim Stuart, Rebecca D. Hodge, Lijuan Hu, Bang-An Wang, Zhuzhu Zhang, Sebastian Preissl, Dong-Sung Lee, Jingtian Zhou, Sheng-Yong Niu, Rosa Castanon, Anna Bartlett, Angeline Rivkin, Xinxin Wang, Jacinta Lucero, Joseph R. Nery, David A. Davis, Deborah C. Mash, Rahul Satija, Jesse R. Dixon, Sten Linnarsson, Ed Lein, M. Margarita Behrens, Bing Ren, Eran A. Mukamel, Joseph R. Ecker
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Cell Genomics
Subjects:
brain
methylation
multi-omics
single cell
epigenomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2666979X22000271

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http://www.sciencedirect.com/science/article/pii/S2666979X22000271

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