Bilirubin Improves Gap Junction to Alleviate Doxorubicin-Induced Cardiotoxicity by Regulating AMPK-Axl-SOCS3-Cx43 Axis

Bilirubin Improves Gap Junction to Alleviate Doxorubicin-Induced Cardiotoxicity by Regulating AMPK-Axl-SOCS3-Cx43 Axis

Doxorubicin induces severe cardiotoxicity, accompanied by the high level of bilirubin in the blood. The conventional wisdom is that bilirubin is considered as a marker of liver damage. By contrast, here we aim to explore the potential protective effect of bilirubin on doxorubicin-induced cardiotoxic...

Full description

Bibliographic Details
Main Authors: Siqi Zhang, Yixin Fan, Binbin Zheng, Yu Wang, Chen Miao, Yue Su, Kun Li, Yan E., Xueli Wang, Xueming He, Xuefeng Wu, Chenjie Xu, Yulin Tang, Wen-Tao Liu, Xiangqing Kong, Liang Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
doxorubicin
bilirubin
cardiotoxicity
Cx43 gap junction
AMPK
SOCS3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.828890/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.828890/full

Similar Items