An enzymatic activation of formaldehyde for nucleotide methylation

An enzymatic activation of formaldehyde for nucleotide methylation

The bacterial thymidylate synthase ThyX catalyzes the reductive methylation of deoxyuridylate (dUMP) into deoxythymidylate (dTMP) and requires both folate and flavin for activity. Here, the authors combine biochemical experiments, spectroscopic measurements and flavin synthesis chemistry to show tha...

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Bibliographic Details
Main Authors: Charles Bou-Nader, Frederick W. Stull, Ludovic Pecqueur, Philippe Simon, Vincent Guérineau, Antoine Royant, Marc Fontecave, Murielle Lombard, Bruce A. Palfey, Djemel Hamdane
Format: Article
Language:English
Published: Nature Portfolio 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24756-8

Internet

https://doi.org/10.1038/s41467-021-24756-8

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