Post-Catalytic Complexes with Emtricitabine or Stavudine and HIV-1 Reverse Transcriptase Reveal New Mechanistic Insights for Nucleotide Incorporation and Drug Resistance

Post-Catalytic Complexes with Emtricitabine or Stavudine and HIV-1 Reverse Transcriptase Reveal New Mechanistic Insights for Nucleotide Incorporation and Drug Resistance

Human immunodeficiency virus 1 (HIV-1) infection is a global health issue since neither a cure nor a vaccine is available. However, the highly active antiretroviral therapy (HAART) has improved the life expectancy for patients with acquired immunodeficiency syndrome (AIDS). Nucleoside reverse transc...

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Detalles Bibliográficos
Autores principales: Nicole Bertoletti, Albert H. Chan, Raymond F. Schinazi, Karen S. Anderson
Formato: Artículo
Lenguaje:English
Publicado: MDPI AG 2020-10-01
Colección:Molecules
Materias:
nucleoside reverse transcriptase inhibitors
emtricitabine
stavudine
inhibitor-protein complexes
macromolecular X-ray crystallography
Acceso en línea:https://www.mdpi.com/1420-3049/25/20/4868

Internet

https://www.mdpi.com/1420-3049/25/20/4868

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