Identification of Variants (rs11571707, rs144848, and rs11571769) in the <i>BRCA2</i> Gene Associated with Hereditary Breast Cancer in Indigenous Populations of the Brazilian Amazon

Identification of Variants (rs11571707, rs144848, and rs11571769) in the <i>BRCA2</i> Gene Associated with Hereditary Breast Cancer in Indigenous Populations of the Brazilian Amazon

Estimates show that 5–10% of breast cancer cases are hereditary, caused by genetic variants in autosomal dominant genes; of these, 16% are due to germline mutations in the <i>BRCA1</i> and <i>BRCA2</i> genes. The comprehension of the mutation profile of these genes in the Bra...

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Bibliographic Details
Main Authors: Elizabeth Ayres Fragoso Dobbin, Jéssyca Amanda Gomes Medeiros, Marta Solange Camarinha Ramos Costa, Juliana Carla Gomes Rodrigues, João Farias Guerreiro, José Eduardo Kroll, Sandro José de Souza, Paulo Pimentel de Assumpção, Ândrea Ribeiro-dos-Santos, Sidney Emanuel Batista dos Santos, Rommel Mario Rodríguez Burbano, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Genes
Subjects:
hereditary breast cancer
<i>BRCA1</i>
<i>BRCA2</i>
indigenous populations
Native Americans
Brazil
Online Access:https://www.mdpi.com/2073-4425/12/2/142

Internet

https://www.mdpi.com/2073-4425/12/2/142

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