Generation of PCBP1-deficient pigs using CRISPR/Cas9-mediated gene editing

Generation of PCBP1-deficient pigs using CRISPR/Cas9-mediated gene editing

Summary: Classical swine fever virus (CSFV), a classic swine fever pathogen, causes severe economic losses worldwide. Poly (rC)-binding protein 1 (PCBP1), which interacts with Npro of CSFV, plays a vital role in CSFV growth. We are the first to report the generation of PCBP1-deficient pigs via gene-...

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Bibliographic Details
Main Authors: Chunyun Qi, Daxin Pang, Kang Yang, Shuyu Jiao, Heyong Wu, Chuheng Zhao, Lanxin Hu, Feng Li, Jian Zhou, Lin Yang, Dongmei Lv, Xiaochun Tang, Hongsheng Ouyang, Zicong Xie
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Virology
Animal biotechnology
Model organism
Animal health management
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222015401

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http://www.sciencedirect.com/science/article/pii/S2589004222015401

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