Enhancement of Phosphorylation and Transport Activity of the Neuronal Glutamate Transporter Excitatory Amino Acid Transporter 3 by C3bot and a 26mer C3bot Peptide

Enhancement of Phosphorylation and Transport Activity of the Neuronal Glutamate Transporter Excitatory Amino Acid Transporter 3 by C3bot and a 26mer C3bot Peptide

In primary murine hippocampal neurons we investigated the regulation of EAAT3-mediated glutamate transport by the Clostridium botulinum C3 transferase C3bot and a 26mer peptide derived from full length protein. Incubation with either enzyme-competent C3bot or enzyme-deficient C3bot156–181 peptide re...

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Bibliographic Details
Main Authors: Johannes Piepgras, Astrid Rohrbeck, Ingo Just, Stefan Bittner, Gudrun Ahnert-Hilger, Markus Höltje
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
C3 transferase
glutamate transporter
EAAT3
phosphorylation
uptake
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.860823/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.860823/full

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