PARP2 downregulation in T cells ameliorates lipopolysaccharide-induced inflammation of the large intestine

PARP2 downregulation in T cells ameliorates lipopolysaccharide-induced inflammation of the large intestine

IntroductionT cell-dependent inflammatory response with the upregulation of helper 17 T cells (Th17) and the downregulation of regulatory T cells (Treg) accompanied by the increased production of tumor necrosis alpha (TNFa) is characteristic of inflammatory bowel diseases (IBD). Modulation of T cell...

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Main Authors: Máté Bencsics, Bálint Bányai, Haoran Ke, Roland Csépányi-Kömi, Péter Sasvári, Françoise Dantzer, Najat Hanini, Rita Benkő, Eszter M. Horváth
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
colitis
IBD - inflammatory bowel disease
PARP (poly(ADP-ribose) polymerase
PARP2
T lymphocyte
regulatory (Treg) cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1135410/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1135410/full

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