Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability

Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability

The heterochromatin spreading reaction is a central contributor to the formation of gene-repressive structures, which are re-established with high positional precision, or fidelity, following replication. How the spreading reaction contributes to this fidelity is not clear. To resolve the origins of...

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Bibliographic Details
Main Authors: R A Greenstein, Stephen K Jones, Eric C Spivey, James R Rybarski, Ilya J Finkelstein, Bassem Al-Sady
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
heterochromatin spreading
multigenerational single cell tracking
epigenetic inheritance
cellular identity
epigenetics and environment
histone turnover
Online Access:https://elifesciences.org/articles/32948

Internet

https://elifesciences.org/articles/32948

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