HIV-1 Reverse Transcriptase Expression in HPV16-Infected Epidermoid Carcinoma Cells Alters E6 Expression and Cellular Metabolism, and Induces a Hybrid Epithelial/Mesenchymal Cell Phenotype

HIV-1 Reverse Transcriptase Expression in HPV16-Infected Epidermoid Carcinoma Cells Alters E6 Expression and Cellular Metabolism, and Induces a Hybrid Epithelial/Mesenchymal Cell Phenotype

The high incidence of epithelial malignancies in HIV-1 infected individuals is associated with co-infection with oncogenic viruses, such as high-risk human papillomaviruses (HR HPVs), mostly HPV16. The molecular mechanisms underlying the HIV-1-associated increase in epithelial malignancies are not f...

Full description

Bibliographic Details
Main Authors: Alla Zhitkevich, Ekaterina Bayurova, Darya Avdoshina, Natalia Zakirova, Galina Frolova, Juris Jansons, Sona Chowdhury, Alexander Ivanov, Ilya Gordeychuk, Joel M. Palefsky, Maria Isaguliants
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Viruses
Subjects:
HIV-1
reverse transcriptase
HPV16-positive cells
E6*I isoform expression
glycolysis
mitochondrial respiration
Online Access:https://www.mdpi.com/1999-4915/16/2/193

Internet

https://www.mdpi.com/1999-4915/16/2/193

Similar Items