New Phenylglycinamide Derivatives with Hybrid Structure as Candidates for New Broad-Spectrum Anticonvulsants

New Phenylglycinamide Derivatives with Hybrid Structure as Candidates for New Broad-Spectrum Anticonvulsants

In the present study, a focused combinatorial chemistry approach was applied to merge structural fragments of well-known TRPV1 antagonists with a potent anticonvulsant lead compound, <b>KA-104</b>, that was previously discovered by our group. Consequently, a series of 22 original compoun...

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Bibliographic Details
Main Authors: Marcin Jakubiec, Michał Abram, Mirosław Zagaja, Marta Andres-Mach, Aleksandra Szewczyk, Gniewomir Latacz, Bartłomiej Szulczyk, Katarzyna Socała, Dorota Nieoczym, Piotr Wlaź, Cameron S. Metcalf, Karen Wilcox, Rafał M. Kamiński, Krzysztof Kamiński
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
hybrid molecules
multimodal/multi-target compounds
amino acid derivatives
antiseizure activity
in vitro binding/functional studies
ADME-Tox properties
Online Access:https://www.mdpi.com/2073-4409/11/12/1862

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https://www.mdpi.com/2073-4409/11/12/1862

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