Mucin 21 confers resistance to apoptosis in an O-glycosylation-dependent manner

Mucin 21 confers resistance to apoptosis in an O-glycosylation-dependent manner

Mucin 21 (MUC21) is a large glycoprotein that protects squamous epithelia. Glycan changes in mucins occur in cancer cells and are thought to contribute to malignant progression. We report glycoform-dependent antiapoptotic effects of MUC21. Various MUC21 glycoforms were expressed in HEK293 and CHO ce...

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Main Authors: Yuan Tian, Kaori Denda-Nagai, Tatsuya Tsukui, Katrin B. Ishii-Schrade, Kyoko Okada, Yoshihiro Nishizono, Kosuke Matsuzaki, Margarete Hafley, Robert S. Bresalier, Tatsuro Irimura
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-01006-4

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https://doi.org/10.1038/s41420-022-01006-4

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