Circulating Exosomal miRNAs Signal Circadian Misalignment to Peripheral Metabolic Tissues

Circulating Exosomal miRNAs Signal Circadian Misalignment to Peripheral Metabolic Tissues

Night shift work increases risk of metabolic disorders, particularly obesity and insulin resistance. While the underlying mechanisms are unknown, evidence points to misalignment of peripheral oscillators causing metabolic disturbances. A pathway conveying such misalignment may involve exosome-based...

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Bibliographic Details
Main Authors: Abdelnaby Khalyfa, Shobhan Gaddameedhi, Elena Crooks, Chunling Zhang, Yan Li, Zhuanhong Qiao, Wojciech Trzepizur, Steve A. Kay, Jorge Andrade, Brieann C. Satterfield, Devon A. Hansen, Leila Kheirandish-Gozal, Hans P. A. Van Dongen, David Gozal
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
Bmal1-dLuc reporter assay
circadian rhythm
clock genes
constant routine
exosomes
extracellular vesicles
Online Access:https://www.mdpi.com/1422-0067/21/17/6396

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https://www.mdpi.com/1422-0067/21/17/6396

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