Case Report: MAP2K1 K57N mutation is associated with primary resistance to anti-EGFR monoclonal antibodies in metastatic colorectal cancer

Case Report: MAP2K1 K57N mutation is associated with primary resistance to anti-EGFR monoclonal antibodies in metastatic colorectal cancer

BackgroundWe aim to identify the prevalence and the role of the MAP2K1 K57N mutation in predicting resistance to anti-EGFR agents in metastatic colorectal cancer (mCRC) patients.MethodsWe retrospectively reviewed tumor-based next generation sequencing (NGS) results from mCRC patients screened for en...

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Bibliographic Details
Main Authors: Gianluca Mauri, Giorgio Patelli, Viviana Gori, Calogero Lauricella, Benedetta Mussolin, Alessio Amatu, Katia Bencardino, Federica Tosi, Erica Bonazzina, Emanuela Bonoldi, Alberto Bardelli, Salvatore Siena, Andrea Sartore-Bianchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Oncology
Subjects:
MAP2K1
MEK
panitumumab
resistance mechanisms
colorectal cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1030232/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1030232/full

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