Design and Production An Effective Bispecific Tandem Chimeric Antigen Receptor on T Cells against CD123 and Folate Receptor ß towards B-Acute Myeloid Leukaemia Blasts

Design and Production An Effective Bispecific Tandem Chimeric Antigen Receptor on T Cells against CD123 and Folate Receptor ß towards B-Acute Myeloid Leukaemia Blasts

Objective: The clinical studies of acute myeloid leukaemia (AML) revealed that antigen escaping variants cause cancer recurrence even after treatment with chimeric antigen receptor (CAR)-T cells that target a single tumour antigen. Due to the heterogeneous expression of antigens on leukaemia blasts,...

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Bibliographic Details
Main Authors: Ali Ghamari, Parviz Pakzad, Ahmad Majd, Marzieh Ebrahimi, Amir Ali Hamidieh
Format: Article
Language:English
Published: Royan Institute (ACECR), Tehran 2021-11-01
Series:Cell Journal
Subjects:
acute myeloid leukaemia
chimeric antigen receptor
cd123
folate receptor β
Online Access:https://celljournal.org/journal/article/fulltext/design-and-production-an-effective-bispecific-tandem-chimeric-antigen-receptor-on-t-cells-against-cd123-and-folate-receptor-b-towards-b-acute-myeloid-leukemia-blasts.pdf

Internet

https://celljournal.org/journal/article/fulltext/design-and-production-an-effective-bispecific-tandem-chimeric-antigen-receptor-on-t-cells-against-cd123-and-folate-receptor-b-towards-b-acute-myeloid-leukemia-blasts.pdf

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