Indian Hedgehog Suppresses a Stromal Cell–Driven Intestinal Immune Response

Indian Hedgehog Suppresses a Stromal Cell–Driven Intestinal Immune Response

Upon intestinal epithelial damage a complex wound healing response is initiated to restore epithelial integrity and defend against pathogenic invasion. Epithelium-derived Indian Hedgehog (Ihh) functions as a critical sensor in this process. Signaling occurs in a paracrine manner because the receptor...

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Bibliographic Details
Main Authors: B. Florien Westendorp, Nikè V.J.A. Büller, Olga N. Karpus, Willemijn A. van Dop, Jan Koster, Rogier Versteeg, Pim J. Koelink, Clinton Y. Snel, Sander Meisner, Joris J.T.H. Roelofs, Anja Uhmann, Emiel Ver Loren van Themaat, Jarom Heijmans, Heidi Hahn, Vanesa Muncan, Manon E. Wildenberg, Gijs R. van den Brink
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Intestine
Hedgehog
Stroma
Inflammation
CXCL12
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X17301340

Internet

http://www.sciencedirect.com/science/article/pii/S2352345X17301340

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