Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis.

Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis.

TL1A is a member of the TNF superfamily and its expression is increased in the mucosa of inflammatory bowel disease patients. Moreover, a subset of Crohn's disease (CD) patients with the risk TL1A haplotype is associated with elevated TL1A expression and a more severe disease course. To investi...

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Bibliographic Details
Main Authors: David Q Shih, Robert Barrett, Xiaolan Zhang, Nicole Yeager, Hon Wai Koon, Piangwarin Phaosawasdi, Yahui Song, Brian Ko, Michelle H Wong, Kathrin S Michelsen, Gislaine Martins, Charalabos Pothoulakis, Stephan R Targan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3019214?pdf=render

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http://europepmc.org/articles/PMC3019214?pdf=render

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