Role of Vitamin C on methotrexate-induced nephrotoxicity in psoriasis context: A preclinical assessment

Role of Vitamin C on methotrexate-induced nephrotoxicity in psoriasis context: A preclinical assessment

Methotrexate (MTX) is the most prescribed drug for systemic treatment of psoriasis. However, its clinical use is limited by its nephrotoxicity, which antioxidants can attenuate. This study evaluates the impact of vitamin C (vitC), a well-known antioxidant, on nephrotoxicity induced by high MTX doses...

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Bibliographic Details
Main Authors: Elodia-Nataly Díaz-de-la-Cruz, Grecia-Elena Hurtado-Nuñez, Sandra-Guadalupe Sánchez-Ceja, Luz Torner, María-Carmen Bartolomé-Camacho, Walter-Ángel Trujillo-Rangel, Martha-Estrella García-Pérez
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Toxicology Reports
Subjects:
Ascorbic acid
Kidney
Methotrexate
Necrosis
Oxidative stress
Psoriasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750024001653

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http://www.sciencedirect.com/science/article/pii/S2214750024001653

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