Alterations to parvalbumin-expressing interneuron function and associated network oscillations in the hippocampal – medial prefrontal cortex circuit during natural sleep in AppNL-G-F/NL-G-F mice

Alterations to parvalbumin-expressing interneuron function and associated network oscillations in the hippocampal – medial prefrontal cortex circuit during natural sleep in AppNL-G-F/NL-G-F mice

In the early stages of Alzheimer's disease (AD), the accumulation of the peptide amyloid-β (Aβ) damages synapses and disrupts neuronal activity, leading to the disruption of neuronal oscillations associated with cognition. This is thought to be largely due to impairments in CNS synaptic inhibit...

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Bibliographic Details
Main Authors: Erica S. Brady, Jessica Griffiths, Lilya Andrianova, Monika H. Bielska, Takashi Saito, Takaomi C. Saido, Andrew D. Randall, Francesco Tamagnini, Jonathan Witton, Michael T. Craig
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Neuronal oscillation
Parvalbumin interneuron
Amyloid
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123001651

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http://www.sciencedirect.com/science/article/pii/S0969996123001651

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