Resistance to enzymatic degradation and efficacy evaluation of crosslinked hyaluronic acid based commercial viscosupplements for knee osteoarthritis treatment
A significant number of people worldwide suffers from knee osteoarthritis (KOA), a chronic and painful disease that is linked to aging, traumatological events and sports medicine. Clinical research indicates that KOA exhibit an altered synovial fluid (SF) with lower endogenous hyaluronic acid (HA) c...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893923001135 |
| _version_ | 1827577199590375424 |
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| author | Jon Andrade del Olmo Virginia Sáez Martínez Nagore Martínez de Cestafe José María Alonso Claudia Goenaga Ibeas Miguel Ucelay López de Heredia Sandra Benito Cid Raúl Pérez González |
| author_facet | Jon Andrade del Olmo Virginia Sáez Martínez Nagore Martínez de Cestafe José María Alonso Claudia Goenaga Ibeas Miguel Ucelay López de Heredia Sandra Benito Cid Raúl Pérez González |
| author_sort | Jon Andrade del Olmo |
| collection | DOAJ |
| description | A significant number of people worldwide suffers from knee osteoarthritis (KOA), a chronic and painful disease that is linked to aging, traumatological events and sports medicine. Clinical research indicates that KOA exhibit an altered synovial fluid (SF) with lower endogenous hyaluronic acid (HA) concentration and viscoelastic properties. Nowadays, viscosupplementation by intra-articular HA injections is the most common treatment to restore endogenous HA performance in osteoarthritic SF. In this work, TrHCROSS®, Durolane®, Regenflex®Bio-plus and Monovisc® commercial crosslinked HA viscosupplements were compared in vitro against enzymatic degradation. As key research point, TrHCROSS® demonstrated a considerably increased enzymatic stability compared to the rest of examined viscosupplements, which highlights TrHCROSS® prolonged residence time in joint space reducing more durably and effectively osteoarthritic knee pain. Subsequently, an in-depth physicochemical characterization was realized to support efficacy and stability results of viscosupplements. All in all, TrHCROSS®, developed by SARE® technology, was found to be more successful in treating more durably and effectively KOA based on the remarkable outcomes of conducted trials, which were appropriate findings for the current research investigation. |
| first_indexed | 2024-03-08T21:24:25Z |
| format | Article |
| id | doaj.art-9d51bda6df1a4e6b944559cd4f925ea2 |
| institution | Directory Open Access Journal |
| issn | 2666-8939 |
| language | English |
| last_indexed | 2024-03-08T21:24:25Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj.art-9d51bda6df1a4e6b944559cd4f925ea22023-12-21T07:37:50ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392023-12-016100392Resistance to enzymatic degradation and efficacy evaluation of crosslinked hyaluronic acid based commercial viscosupplements for knee osteoarthritis treatmentJon Andrade del Olmo0Virginia Sáez Martínez1Nagore Martínez de Cestafe2José María Alonso3Claudia Goenaga Ibeas4Miguel Ucelay López de Heredia5Sandra Benito Cid6Raúl Pérez González7Corresponding author.; i+Med S. Coop., Alava Technology Park, Albert Einstein 15, Nave 15, Vitoria-Gasteiz 01510, Spaini+Med S. Coop., Alava Technology Park, Albert Einstein 15, Nave 15, Vitoria-Gasteiz 01510, Spaini+Med S. Coop., Alava Technology Park, Albert Einstein 15, Nave 15, Vitoria-Gasteiz 01510, Spaini+Med S. Coop., Alava Technology Park, Albert Einstein 15, Nave 15, Vitoria-Gasteiz 01510, Spaini+Med S. Coop., Alava Technology Park, Albert Einstein 15, Nave 15, Vitoria-Gasteiz 01510, Spaini+Med S. Coop., Alava Technology Park, Albert Einstein 15, Nave 15, Vitoria-Gasteiz 01510, Spaini+Med S. Coop., Alava Technology Park, Albert Einstein 15, Nave 15, Vitoria-Gasteiz 01510, Spaini+Med S. Coop., Alava Technology Park, Albert Einstein 15, Nave 15, Vitoria-Gasteiz 01510, SpainA significant number of people worldwide suffers from knee osteoarthritis (KOA), a chronic and painful disease that is linked to aging, traumatological events and sports medicine. Clinical research indicates that KOA exhibit an altered synovial fluid (SF) with lower endogenous hyaluronic acid (HA) concentration and viscoelastic properties. Nowadays, viscosupplementation by intra-articular HA injections is the most common treatment to restore endogenous HA performance in osteoarthritic SF. In this work, TrHCROSS®, Durolane®, Regenflex®Bio-plus and Monovisc® commercial crosslinked HA viscosupplements were compared in vitro against enzymatic degradation. As key research point, TrHCROSS® demonstrated a considerably increased enzymatic stability compared to the rest of examined viscosupplements, which highlights TrHCROSS® prolonged residence time in joint space reducing more durably and effectively osteoarthritic knee pain. Subsequently, an in-depth physicochemical characterization was realized to support efficacy and stability results of viscosupplements. All in all, TrHCROSS®, developed by SARE® technology, was found to be more successful in treating more durably and effectively KOA based on the remarkable outcomes of conducted trials, which were appropriate findings for the current research investigation.http://www.sciencedirect.com/science/article/pii/S2666893923001135Hyaluronic acidCommercial injectable hydrogelsViscosupplementationKnee osteoarthritisTraumatologySports medicine |
| spellingShingle | Jon Andrade del Olmo Virginia Sáez Martínez Nagore Martínez de Cestafe José María Alonso Claudia Goenaga Ibeas Miguel Ucelay López de Heredia Sandra Benito Cid Raúl Pérez González Resistance to enzymatic degradation and efficacy evaluation of crosslinked hyaluronic acid based commercial viscosupplements for knee osteoarthritis treatment Carbohydrate Polymer Technologies and Applications Hyaluronic acid Commercial injectable hydrogels Viscosupplementation Knee osteoarthritis Traumatology Sports medicine |
| title | Resistance to enzymatic degradation and efficacy evaluation of crosslinked hyaluronic acid based commercial viscosupplements for knee osteoarthritis treatment |
| title_full | Resistance to enzymatic degradation and efficacy evaluation of crosslinked hyaluronic acid based commercial viscosupplements for knee osteoarthritis treatment |
| title_fullStr | Resistance to enzymatic degradation and efficacy evaluation of crosslinked hyaluronic acid based commercial viscosupplements for knee osteoarthritis treatment |
| title_full_unstemmed | Resistance to enzymatic degradation and efficacy evaluation of crosslinked hyaluronic acid based commercial viscosupplements for knee osteoarthritis treatment |
| title_short | Resistance to enzymatic degradation and efficacy evaluation of crosslinked hyaluronic acid based commercial viscosupplements for knee osteoarthritis treatment |
| title_sort | resistance to enzymatic degradation and efficacy evaluation of crosslinked hyaluronic acid based commercial viscosupplements for knee osteoarthritis treatment |
| topic | Hyaluronic acid Commercial injectable hydrogels Viscosupplementation Knee osteoarthritis Traumatology Sports medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2666893923001135 |
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