Lipopolysaccharide pretreatment increases the sensitivity of the TRPV1 channel and promotes an anti-inflammatory phenotype of capsaicin-activated macrophages

Lipopolysaccharide pretreatment increases the sensitivity of the TRPV1 channel and promotes an anti-inflammatory phenotype of capsaicin-activated macrophages

Abstract Background The transient receptor potential vanilloid 1 (TRPV1) is well-established in neuronal function, yet its role in immune reactions remains enigmatic. The conflicting data on its inflammatory role, suggesting both pro-inflammatory and anti-inflammatory effects upon TRPV1 stimulation...

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Bibliographic Details
Main Authors: Daniel Vašek, Natálie Fikarová, Vendula Nagy Marková, Ondřej Honc, Lenka Pacáková, Bianka Porubská, Veronika Somova, Jiří Novotný, Barbora Melkes, Magdaléna Krulová
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Journal of Inflammation
Subjects:
TRPV1
Macrophages
Capsaicin
Inflammation
Online Access:https://doi.org/10.1186/s12950-024-00391-0

Internet

https://doi.org/10.1186/s12950-024-00391-0

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