Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells

Extracellular vesicles containing oncogenic mutant β-catenin activate Wnt signalling pathway in the recipient cells

Mutations in β-catenin, especially at the residues critical for its degradation, render it constitutively active. Here, we show that mutant β-catenin can be transported via extracellular vesicles (EVs) and activate Wnt signalling pathway in the recipient cells. An integrative proteogenomic analysis...

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Bibliographic Details
Main Authors: Hina Kalra, Lahiru Gangoda, Pamali Fonseka, Sai V. Chitti, Michael Liem, Shivakumar Keerthikumar, Monisha Samuel, Stephanie Boukouris, Haidar Al Saffar, Christine Collins, Christopher G. Adda, Ching-Seng Ang, Suresh Mathivanan
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Journal of Extracellular Vesicles
Subjects:
exosomes
extracellular vesicles
colorectal cancer
proteomics
wnt signalling
β-catenin
tumour microenvironment
Online Access:http://dx.doi.org/10.1080/20013078.2019.1690217

Internet

http://dx.doi.org/10.1080/20013078.2019.1690217

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