Overexpression of Substance P in pig airways increases MUC5AC through an NF‐kβ pathway

Overexpression of Substance P in pig airways increases MUC5AC through an NF‐kβ pathway

Abstract Substance P (SP) is a tachykinin that regulates airway mucous secretion in both health and disease. Our study aimed to determine whether overexpression of SP without pre‐existing inflammation was sufficient to induce changes in mucin secretion and transport in small airways. Utilizing porci...

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Bibliographic Details
Main Authors: Mariana Sponchiado, Yan‐Shin Liao, Kalina R. Atanasova, Emily N. Collins, Veronica Schurmann, Laura Bravo, Leah R. Reznikov
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Physiological Reports
Subjects:
MUC5AC
MUC5B
neuropeptides
tachykinins
Online Access:https://doi.org/10.14814/phy2.14749

Internet

https://doi.org/10.14814/phy2.14749

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