The multifaceted roles of cohesin in cancer

Abstract The cohesin complex controls faithful chromosome segregation by pairing sister chromatids after DNA replication until mitosis. In addition, it is crucial for hierarchal three-dimensional organization of the genome, transcription regulation and maintaining DNA integrity. The core complex sub...

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Bibliographic Details
Main Authors: Maddalena Di Nardo, Maria M. Pallotta, Antonio Musio
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Online Access:https://doi.org/10.1186/s13046-022-02321-5