The multifaceted roles of cohesin in cancer
Abstract The cohesin complex controls faithful chromosome segregation by pairing sister chromatids after DNA replication until mitosis. In addition, it is crucial for hierarchal three-dimensional organization of the genome, transcription regulation and maintaining DNA integrity. The core complex sub...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13046-022-02321-5 |
| _version_ | 1818321221255692288 |
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| author | Maddalena Di Nardo Maria M. Pallotta Antonio Musio |
| author_facet | Maddalena Di Nardo Maria M. Pallotta Antonio Musio |
| author_sort | Maddalena Di Nardo |
| collection | DOAJ |
| description | Abstract The cohesin complex controls faithful chromosome segregation by pairing sister chromatids after DNA replication until mitosis. In addition, it is crucial for hierarchal three-dimensional organization of the genome, transcription regulation and maintaining DNA integrity. The core complex subunits SMC1A, SMC3, STAG1/2, and RAD21 as well as its modulators, have been found to be recurrently mutated in human cancers. The mechanisms by which cohesin mutations trigger cancer development and disease progression are still poorly understood. Since cohesin is involved in a range of chromosome-related processes, the outcome of cohesin mutations in cancer is complex. Herein, we discuss recent discoveries regarding cohesin that provide new insight into its role in tumorigenesis. |
| first_indexed | 2024-12-13T10:37:27Z |
| format | Article |
| id | doaj.art-9d54806884c14fed838a63b7cd7b41ad |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-12-13T10:37:27Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-9d54806884c14fed838a63b7cd7b41ad2022-12-21T23:50:41ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662022-03-0141111110.1186/s13046-022-02321-5The multifaceted roles of cohesin in cancerMaddalena Di Nardo0Maria M. Pallotta1Antonio Musio2Institute for Biomedical Technologies (ITB), National Research Council (CNR)Institute for Biomedical Technologies (ITB), National Research Council (CNR)Institute for Biomedical Technologies (ITB), National Research Council (CNR)Abstract The cohesin complex controls faithful chromosome segregation by pairing sister chromatids after DNA replication until mitosis. In addition, it is crucial for hierarchal three-dimensional organization of the genome, transcription regulation and maintaining DNA integrity. The core complex subunits SMC1A, SMC3, STAG1/2, and RAD21 as well as its modulators, have been found to be recurrently mutated in human cancers. The mechanisms by which cohesin mutations trigger cancer development and disease progression are still poorly understood. Since cohesin is involved in a range of chromosome-related processes, the outcome of cohesin mutations in cancer is complex. Herein, we discuss recent discoveries regarding cohesin that provide new insight into its role in tumorigenesis.https://doi.org/10.1186/s13046-022-02321-5CohesinTopologically associated domainsGene expression regulationCancerChromosome aneuploidyDNA repair |
| spellingShingle | Maddalena Di Nardo Maria M. Pallotta Antonio Musio The multifaceted roles of cohesin in cancer Journal of Experimental & Clinical Cancer Research Cohesin Topologically associated domains Gene expression regulation Cancer Chromosome aneuploidy DNA repair |
| title | The multifaceted roles of cohesin in cancer |
| title_full | The multifaceted roles of cohesin in cancer |
| title_fullStr | The multifaceted roles of cohesin in cancer |
| title_full_unstemmed | The multifaceted roles of cohesin in cancer |
| title_short | The multifaceted roles of cohesin in cancer |
| title_sort | multifaceted roles of cohesin in cancer |
| topic | Cohesin Topologically associated domains Gene expression regulation Cancer Chromosome aneuploidy DNA repair |
| url | https://doi.org/10.1186/s13046-022-02321-5 |
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