CREB Ameliorates Osteoarthritis Progression Through Regulating Chondrocytes Autophagy via the miR-373/METTL3/TFEB Axis

CREB Ameliorates Osteoarthritis Progression Through Regulating Chondrocytes Autophagy via the miR-373/METTL3/TFEB Axis

Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation. Dysregulated autophagy is a major cause of OA. However, the underlying mechanism is unclear. Here, we found that the expression of element-binding protein (CREB) was downregulated in both cartilage...

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Bibliographic Details
Main Authors: Haibin Zhang, Xilei Li, Yusheng Li, Xucheng Yang, Runzhi Liao, Haoyi Wang, Junxiao Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
osteoarthritis
autophagy
CREB
METTL3
miR-373
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.778941/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.778941/full

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