Detrimental Effects of ApoE ε4 on Blood–Brain Barrier Integrity and Their Potential Implications on the Pathogenesis of Alzheimer’s Disease

Detrimental Effects of ApoE ε4 on Blood–Brain Barrier Integrity and Their Potential Implications on the Pathogenesis of Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disease representing the most common type of dementia in older adults. The major risk factors include increased age, genetic predisposition and socioeconomic factors. Among the genetic factors, the apolipoprotein E (ApoE) ε4 allele poses th...

Full description

Bibliographic Details
Main Authors: Kevin Kirchner, Linda Garvert, Luise Kühn, Sarah Bonk, Hans Jörgen Grabe, Sandra Van der Auwera
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cells
Subjects:
apolipoprotein E
amyloid beta
blood–brain barrier
cyclophilin A
low-density lipoprotein receptor-related protein1
matrix metalloproteinase 9
Online Access:https://www.mdpi.com/2073-4409/12/21/2512

Internet

https://www.mdpi.com/2073-4409/12/21/2512

Similar Items