LRRK2 Knockout Confers Resistance in HEK-293 Cells to Rotenone-Induced Oxidative Stress, Mitochondrial Damage, and Apoptosis

LRRK2 Knockout Confers Resistance in HEK-293 Cells to Rotenone-Induced Oxidative Stress, Mitochondrial Damage, and Apoptosis

Leucine-rich repeat kinase 2 (LRRK2) has been linked to dopaminergic neuronal vulnerability to oxidative stress (OS), mitochondrial impairment, and increased cell death in idiopathic and familial Parkinson’s disease (PD). However, how exactly this kinase participates in the OS-mitochondria-apoptosis...

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Bibliographic Details
Main Authors: Diana Alejandra Quintero-Espinosa, Sabina Sanchez-Hernandez, Carlos Velez-Pardo, Francisco Martin, Marlene Jimenez-Del-Rio
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
clustered regularly interspaced short palindromic repeats
gene edition
human embryonic kidney cell line 293
knockout
Leucine-rich repeat kinase 2
Online Access:https://www.mdpi.com/1422-0067/24/13/10474

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https://www.mdpi.com/1422-0067/24/13/10474

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