In Vitro and In Vivo Therapeutic Potential of 6,6′-Dihydroxythiobinupharidine (DTBN) from <i>Nuphar lutea</i> on Cells and K18-<i>hACE2</i> Mice Infected with SARS-CoV-2

In Vitro and In Vivo Therapeutic Potential of 6,6′-Dihydroxythiobinupharidine (DTBN) from <i>Nuphar lutea</i> on Cells and K18-<i>hACE2</i> Mice Infected with SARS-CoV-2

We have previously published research on the anti-viral properties of an alkaloid mixture extracted from <i>Nuphar lutea</i>, the major components of the partially purified mixture found by NMR analysis. These are mostly dimeric sesquiterpene thioalkaloids called thiobinupharidines and t...

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Bibliographic Details
Main Authors: Shay Weiss, Kamran Waidha, Saravanakumar Rajendran, Daniel Benharroch, Jannat Khalilia, Haim Levy, Elad Bar-David, Avi Golan-Goldhirsh, Jacob Gopas, Amir Ben-Shmuel
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
SARS-CoV-2
COVID-19
6,6′-dihydroxythiobinupharidine (DTBN)
RNA-dependent RNA polymerase (RdRp)
anti-viral small molecule drug
Online Access:https://www.mdpi.com/1422-0067/24/9/8327

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https://www.mdpi.com/1422-0067/24/9/8327

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