Differences in expression rather than methylation at placenta-specific imprinted loci is associated with intrauterine growth restriction

Differences in expression rather than methylation at placenta-specific imprinted loci is associated with intrauterine growth restriction

Abstract Background Genome-wide studies have begun to link subtle variations in both allelic DNA methylation and parent-of-origin genetic effects with early development. Numerous reports have highlighted that the placenta plays a critical role in coordinating fetal growth, with many key functions re...

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Bibliographic Details
Main Authors: Ana Monteagudo-Sánchez, Marta Sánchez-Delgado, Jose Ramon Hernandez Mora, Nuria Tubío Santamaría, Eduard Gratacós, Manel Esteller, Miguel López de Heredia, Virgina Nunes, Cecile Choux, Patricia Fauque, Guiomar Perez de Nanclares, Lauren Anton, Michal A. Elovitz, Isabel Iglesias-Platas, David Monk
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Clinical Epigenetics
Subjects:
Imprinting
Placenta
DNA methylation
Epigenetics
Online Access:http://link.springer.com/article/10.1186/s13148-019-0630-4

Internet

http://link.springer.com/article/10.1186/s13148-019-0630-4

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