Quantification of dynamic morphological drug responses in 3D organotypic cell cultures by automated image analysis.

Quantification of dynamic morphological drug responses in 3D organotypic cell cultures by automated image analysis.

Glandular epithelial cells differentiate into complex multicellular or acinar structures, when embedded in three-dimensional (3D) extracellular matrix. The spectrum of different multicellular morphologies formed in 3D is a sensitive indicator for the differentiation potential of normal, non-transfor...

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Bibliographic Details
Main Authors: Ville Härmä, Hannu-Pekka Schukov, Antti Happonen, Ilmari Ahonen, Johannes Virtanen, Harri Siitari, Malin Åkerfelt, Jyrki Lötjönen, Matthias Nees
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4014501?pdf=render

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http://europepmc.org/articles/PMC4014501?pdf=render

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