Inhibitory Effects of 2N1HIA (2-(3-(2-Fluoro-4-Methoxyphenyl)-6-Oxo-1(6H)-Pyridazinyl)-<i>N</i>-1H-Indol-5-Ylacetamide) on Osteoclast Differentiation via Suppressing Cathepsin K Expression

Inhibitory Effects of 2N1HIA (2-(3-(2-Fluoro-4-Methoxyphenyl)-6-Oxo-1(6H)-Pyridazinyl)-<i>N</i>-1H-Indol-5-Ylacetamide) on Osteoclast Differentiation via Suppressing Cathepsin K Expression

Osteoclasts are large multinucleated cells which are induced by the regulation of the receptor activator of nuclear factor kappa-&#914; ligand (RANKL), which is important in bone resorption. Excessive osteoclast differentiation can cause pathologic bone loss and destruction. Numerous studies hav...

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Bibliographic Details
Main Authors: Sun-Hee Ahn, Zhihao Chen, Jinkyung Lee, Seok-Woo Lee, Sang Hyun Min, Nam Doo Kim, Tae-Hoon Lee
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
osteoclast
cathepsin K
osteoporosis
bone resorption
Online Access:https://www.mdpi.com/1420-3049/23/12/3139

Internet

https://www.mdpi.com/1420-3049/23/12/3139

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