TRPV4 Blockade Preserves the Blood–Brain Barrier by Inhibiting Stress Fiber Formation in a Rat Model of Intracerebral Hemorrhage

TRPV4 Blockade Preserves the Blood–Brain Barrier by Inhibiting Stress Fiber Formation in a Rat Model of Intracerebral Hemorrhage

Blood–brain barrier (BBB) disruption and subsequent brain edema play important roles in the secondary neuronal death and neurological dysfunction that are observed following intracerebral hemorrhage (ICH). In previous studies, transient receptor potential vanilloid 4 (TRPV4), a calcium-permeable mec...

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Bibliographic Details
Main Authors: Hengli Zhao, Kaiyuan Zhang, Rongrui Tang, Hui Meng, Yongjie Zou, Pengfei Wu, Rong Hu, Xin Liu, Hua Feng, Yujie Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
blood–brain barrier
intracerebral hemorrhage
transient receptor potential vanilloid 4
stress fibers
secondary brain injury
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00097/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00097/full

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