Premorbid performances determine the deleterious effects of nigrostriatal degeneration and pramipexole on behavioural flexibility

Abstract Subtle cognitive impairment can occur early in the course of Parkinson’s disease (PD) and may manifest under different forms of executive dysfunction such as impaired cognitive flexibility. The precise contribution of nigrostriatal dopaminergic neurodegeneration to these non-motor features...

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Bibliographic Details
Main Authors: Mélina Decourt, Eric Balado, Maureen Francheteau, Marcello Solinas, Marianne Benoît-Marand, Pierre-Olivier Fernagut
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-023-00475-3