Leaf-venation-directed cellular alignment for macroscale cardiac constructs with tissue-like functionalities

Abstract Recapitulating the complex structural, mechanical, and electrophysiological properties of native myocardium is crucial to engineering functional cardiac tissues. Here, we report a leaf-venation-directed strategy that enables the compaction and remodeling of cell-hydrogel hybrids into highly...

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Bibliographic Details
Main Authors: Mao Mao, Xiaoli Qu, Yabo Zhang, Bingsong Gu, Chen Li, Rongzhi Liu, Xiao Li, Hui Zhu, Jiankang He, Dichen Li
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37716-1