Membrane vesicles from Lactobacillus johnsonii delay osteoarthritis progression via modulating macrophage glutamine synthetase/mTORC1 axis

Membrane vesicles from Lactobacillus johnsonii delay osteoarthritis progression via modulating macrophage glutamine synthetase/mTORC1 axis

Aims: The manipulation of macrophage recruitment and their shift in the M1/M2 ratio is a promising approach to mitigate osteoarthritis (OA). Nevertheless, the current clinical medication available for OA is only palliative and may result in undesirable outcomes. Hence, it is urgent to explore altern...

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Bibliographic Details
Main Authors: Rangru Liu, Yue Zhou, Huanxiong Chen, Haixia Xu, Min Zuo, Bo Chen, Hua Wang
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Probiotic-derived membrane vesicles
Synovial macrophage
Migration
Reprogramming
Lactobacillus johnsonii
Chondrocyte anabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223009952

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http://www.sciencedirect.com/science/article/pii/S0753332223009952

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