Extensive downregulation of immune gene expression by microRNA-140-3p 5′ isomiR in an in vitro model of osteoarthritis

Objective: MicroRNA-140-3p is the most prevalent form of canonical miR-140 in native chondrocytes. IsomiRs are sequence variants of microRNAs with potentially distinct functionalities. Here we present functional studies of canonical microRNA-140-3p and two of its most prevalent isomiRs, a 5′ isomiR...

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Bibliographic Details
Main Authors: Rua Nader Al-Modawi, Jan E. Brinchmann, Tommy A. Karlsen
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Osteoarthritis and Cartilage Open
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2665913121000522