Cholesterol‐Amino‐Phosphate (CAP) Derived Lipid Nanoparticles for Delivery of Self‐Amplifying RNA and Restoration of Spermatogenesis in Infertile Mice

Cholesterol‐Amino‐Phosphate (CAP) Derived Lipid Nanoparticles for Delivery of Self‐Amplifying RNA and Restoration of Spermatogenesis in Infertile Mice

Abstract Male infertility caused by genetic mutations is an important type of infertility. Currently, there is no reliable method in the clinic to address this medical need. The emergence of mRNA therapy provides a possible strategy for restoring mutant genes in the reproductive system. However, eff...

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Bibliographic Details
Main Authors: Shi Du, Wenqing Li, Yuebao Zhang, Yonger Xue, Xucheng Hou, Jingyue Yan, Jeffrey Cheng, Binbin Deng, David W. McComb, Jennifer Lin, Hong Zeng, Xiaolin Cheng, Darrell J. Irvine, Ron Weiss, Yizhou Dong
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Advanced Science
Subjects:
lipid nanoparticles
male infertility
mRNA therapy
self‐amplifying RNA
spermatocytes delivery
Online Access:https://doi.org/10.1002/advs.202300188

Internet

https://doi.org/10.1002/advs.202300188

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