A B Cell-Driven Autoimmune Pathway Leading to Pathological Hallmarks of Progressive Multiple Sclerosis in the Marmoset Experimental Autoimmune Encephalomyelitis Model

A B Cell-Driven Autoimmune Pathway Leading to Pathological Hallmarks of Progressive Multiple Sclerosis in the Marmoset Experimental Autoimmune Encephalomyelitis Model

The absence of pathological hallmarks of progressive multiple sclerosis (MS) in commonly used rodent models of experimental autoimmune encephalomyelitis (EAE) hinders the development of adequate treatments for progressive disease. Work reviewed here shows that such hallmarks are present in the EAE m...

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Bibliographic Details
Main Authors: Bert A. ’t Hart, Jordon Dunham, Bart W. Faber, Jon D. Laman, Jack van Horssen, Jan Bauer, Yolanda S. Kap
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
animal model
demyelination
experimental autoimmune encephalomyelitis
Epstein–Barr virus
B cell
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00804/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00804/full

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