Dermal fibroblasts are the key sensors of aseptic skin inflammation through interleukin 1 release by lesioned keratinocytes

Dermal fibroblasts are the key sensors of aseptic skin inflammation through interleukin 1 release by lesioned keratinocytes

IL-1 plays a crucial role in triggering sterile inflammation following tissue injury. Although most studies associate IL-1 release by injured cells to the recruitment of neutrophils for tissue repair, the inflammatory cascade involves several molecular and cellular actors whose role remains to be sp...

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Bibliographic Details
Main Authors: Sevda Cordier-Dirikoc, Nathalie Pedretti, Julien Garnier, Sandrine Clarhaut-Charreau, Bernhard Ryffel, Franck Morel, François-Xavier Bernard, Valérie Hamon de Almeida, Jean-Claude Lecron, Jean-François Jégou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
keratinocytes
fibroblasts
IL-1
skin
sterile inflammation
epidermal lesion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.984045/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.984045/full

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