M. tuberculosis relies on trace oxygen to maintain energy homeostasis and survive in hypoxic environments

Summary: The bioenergetic mechanisms by which Mycobacterium tuberculosis survives hypoxia are poorly understood. Current models assume that the bacterium shifts to an alternate electron acceptor or fermentation to maintain membrane potential and ATP synthesis. Counterintuitively, we find here that o...

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Bibliographic Details
Main Authors: Nitin Pal Kalia, Samsher Singh, Kiel Hards, Chen-Yi Cheung, Ekaterina Sviriaeva, Amir Banaei-Esfahani, Ruedi Aebersold, Michael Berney, Gregory M. Cook, Kevin Pethe
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723004552