MET inhibitors for targeted therapy of EGFR TKI-resistant lung cancer

Abstract Treatment of non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) activating mutation with EGFR-TKIs has achieved great success, yet faces the development of acquired resistance as the major obstacle to long-term disease remission in the clinic. MET (or c-MET...

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Bibliographic Details
Main Authors: Qiming Wang, Sen Yang, Kai Wang, Shi-Yong Sun
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Hematology & Oncology
Online Access:http://link.springer.com/article/10.1186/s13045-019-0759-9