TNFa and IL2 Encoding Oncolytic Adenovirus Activates Pathogen and Danger-Associated Immunological Signaling

TNFa and IL2 Encoding Oncolytic Adenovirus Activates Pathogen and Danger-Associated Immunological Signaling

In order to break tumor resistance towards traditional treatments, we investigate the response of tumor and immune cells to a novel, cytokine-armed oncolytic adenovirus: Ad5/3-d24-E2F-hTNFa-IRES-hIL2 (also known as TILT-123 and OAd.TNFa-IL2). There are several pattern recognition receptors (PRR) tha...

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Bibliographic Details
Main Authors: Camilla Heiniö, Riikka Havunen, Joao Santos, Klaas de Lint, Victor Cervera-Carrascon, Anna Kanerva, Akseli Hemminki
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
aenovirus
virotherapy
immunotherapy
aim2
oncolytic virus
tilt-123
immunological cell death
damp
pamp
Online Access:https://www.mdpi.com/2073-4409/9/4/798

Internet

https://www.mdpi.com/2073-4409/9/4/798

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