Notch-1 Confers Chemoresistance in Lung Adenocarcinoma to Taxanes through AP-1/microRNA-451 Mediated Regulation of MDR-1

Notch-1 Confers Chemoresistance in Lung Adenocarcinoma to Taxanes through AP-1/microRNA-451 Mediated Regulation of MDR-1

We previously demonstrated that expression of Notch-1 is associated with poor prognosis in lung adenocarcinoma (LAD) patients. The aim of this study is to reveal whether Notch-1 was associated with Taxanes-resistant LAD and, the underlying mechanisms. We collected 39 patients of advanced LAD treated...

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Bibliographic Details
Main Authors: Jiayuan Huang, Yitian Chen, Junyang Li, Kai Zhang, Jing Chen, Dongqin Chen, Bing Feng, Haizhu Song, Jifeng Feng, Rui Wang, Longbang Chen
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
activator protein-1
chemoresistance
lung adenocarcinoma
microRNA
notch signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117301014

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http://www.sciencedirect.com/science/article/pii/S2162253117301014

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