RhoA downregulation in the murine intestinal epithelium results in chronic Wnt activation and increased tumorigenesis

RhoA downregulation in the murine intestinal epithelium results in chronic Wnt activation and increased tumorigenesis

Summary: Rho GTPases are molecular switches regulating multiple cellular processes. To investigate the role of RhoA in normal intestinal physiology, we used a conditional mouse model overexpressing a dominant negative RhoA mutant (RhoAT19N) in the intestinal epithelium. Although RhoA inhibition did...

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Bibliographic Details
Main Authors: Higinio Dopeso, Paulo Rodrigues, Fernando Cartón-García, Irati Macaya, Josipa Bilic, Estefanía Anguita, Li Jing, Bruno Brotons, Núria Vivancos, Laia Beà, Manuel Sánchez-Martín, Stefania Landolfi, Javier Hernandez-Losa, Santiago Ramon y Cajal, Rocío Nieto, María Vicario, Ricard Farre, Simo Schwartz, Jr., Sven C.D. van Ijzendoorn, Kazuto Kobayashi, Águeda Martinez-Barriocanal, Diego Arango
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:iScience
Subjects:
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224006217

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http://www.sciencedirect.com/science/article/pii/S2589004224006217

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