Cell-free DNA measurement of three genomes after allogeneic MSC therapy in kidney transplant recipients indicates early cell death of infused MSC

Cell-free DNA measurement of three genomes after allogeneic MSC therapy in kidney transplant recipients indicates early cell death of infused MSC

IntroductionMesenchymal stromal cell (MSC) therapy is a promising treatment that allows for drug minimization in clinical kidney transplantation. While it is thought that MSCs rapidly go into apoptosis after infusion, clinical evidence for this is scarce since methods to detect cell death of infused...

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Bibliographic Details
Main Authors: Geertje J. Dreyer, Jos JM. Drabbels, Johan W. de Fijter, Cees van Kooten, Marlies EJ. Reinders, Sebastiaan Heidt
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
kidney transplansplantation
mesenchymal stromal cell (MSC)
cell free DNA (cfDNA)
allogeneic MSC
third party MSC
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1240347/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1240347/full

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